Nathalie Lefort has a 15-year experience in human pluripotent stem cell (hPSC) culture and their application for pathological modeling and cell therapy. She worked for 10 years in I-Stem Institute (Institute for Stem cell Therapy and Exploration of Monogenic diseases), pioneer in France in the field of hPSCs. Her work has raised the concern about genetic alteration and contributed to the discovery of a recurrent duplication in hPSCs as well as to the identification of a recurrent translocation occurring in neural derivatives of hPSC. Since july 2015, Nathalie Lefort has established the IPSC core facility of the Imagine Institute. The iPSC core facility allows the development of new cellular models for the study of rare diseases